Dr. Brian Freed, PhD, Chief Science Officer

  • Ph.D., Immunology, Albany Medical College (1990)

  • M.S., Immunology, Albany Medical College (1990)

  • M.A., Virology, State University Of New York, College At Plattsburgh (1978)

  • B.A., Biology, State University of New York at Plattsburgh (1976)

Accreditations:

  • Fellow, American College of Histocompatibility and Immunogenetics (2020)

  • FACT Accredited Director, Stem Cell Processing, Foundation for Accreditation of Cellular Therapy (2008)

  • Director, FDA-licensed public umbilical cord blood banks (FDA Licenses #1855 and #1873)

  • AABB Accredited Director, Umbilical Cord Blood Banking, (2006)

  • Diplomate, American Board of Histocompatibility and Immunogenetics (1999)

Dr. Freed is the Chief Science Officer and Co-Founder of RheumaGen. He is also the Executive Director of ClinImmune Cell & Gene Therapy, Professor of Medicine and Immunology at the University of Colorado School of Medicine, and the inventor of RheumaGen’s breakthrough HLA gene editing technology. Dr. Freed is a world class expert in the HLA gene, with greater than 40 years of experience and more than 100 publications in the areas of immunogenetics, biotherapeutics, histocompatibility, transplantation, and stem cell banking.

Dr. Freed spent most of his early career at Albany Medical College, where he received his PhD in 1990 and was an Assistant Instructor in the Department of Surgery (1984-1990), Assistant Professor of Surgery (1990-1996), Immunology and Molecular Genetics (1991-1996), Pharmacology (1992-1997), and Associate Professor of Surgery (1996-1997), and Pathology and Laboratory Medicine (1996-1997) . Additionally, he was the Supervisor (1981-1991) and then Director (1992-1997) of the Transplantation Immunology Laboratory at Albany Medical College. In 1997 he moved to Denver and the University of Colorado, where he was Director of the University of Colorado Clinical Immunology and Histocompatibility Lab (1997-2001), and Associate Professor of Medicine and Immunology (1997-2003). In 2001, he became the Executive Director of ClinImmune Cell & Gene Therapy, and in 2003 he became Professor of Medicine and Immunology at the University of Colorado School of Medicine. From 1999-2003, he was also the Consulting Director of the Kunming Medical College HLA Laboratory in Kunming, P.R., China. He has been a Member of the Immunological Devices Panel for the U.S. Food and Drug Administration since 2008. Dr. Freed has been the Principal Investigator (PI) or co-investigator on grant projects that have received more than $12 million in funding.

 For Dr. Freed’s full CV and complete list of publications, click here.

Selected Publications:

Clinical Trial Experience:

  • IND #11084 for human islet transplantation at the University of Colorado (2003-2004).

  • IND 10-CBA (sponsored by National Marrow Donor Program) for umbilical cord blood transplantation (2005-present).

  • BLA #1855 for HPC Cord Blood at ClinImmune Labs (May 2012-present).

  • BLA #1873 for AlloCord (HPC Cord Blood) for St. Louis Cord Blood Bank (2018-present).

  • IDE CD34 Isolation from Haploidentical Donors for Cord Blood Transplantation (2018-2022). 

  • IND #18416 Phase I Open Label Safety Study of Umbilical Cord Lining Mesenchymal Stem Cells (CorliCyte®) to Close Chronic Diabetic Wounds (2019-2022).

Patents:

  • U.S. Provisional Patent Application Serial Number 62/655,198: A Method of Transporting Mesenchymal Stem Cells by Means of a Transporting Solution and a Method of Administering Stem Cells to Wounds, filed on April 9, 2018.

  • U.S. Patent PCT/US2018/029302; Methods of Treating Rheumatoid Arthritis Using RNA-Guided Genome Editing of HLA Gene, International filing April 25, 2018.

  • U.S. Patent PCT/US2022/028645; Pocket Engineering of HLA Alleles for Treating Autoimmunity, filed May 10, 2022.